The Detroit Post
Thursday, 21 October, 2021

Is Rust Tetanus

Maria Garcia
• Saturday, 31 October, 2020
• 17 min read

Tetanus is caused by a bacteria called Clostridium retain, which makes its home in soil, dust, and feces. Nails are a common route for infection because C. retain thrives in an oxygen-deprived setting like the one far below your skin's surface.

tetanus rust discovery shutterstock


Tetanus, or lockjaw, is a bacterial infection caused by Clostridium retain, an extremely hardy rod-shaped bacterium found in animal digestive tracts and soil worldwide. The reason we associate tetanus with rust is that it’s often found in soil that’s rich in organic material like manure or dead leaves.

So if your skin is pierced from anything from your own kitchen knife to a rusty gnarled screw, or if you begin working on a farm, it's worth making sure that your tetanus shot is up to date. Although some medical researches observe that tetanus struck is rare, people have full concerns about the disease.

Nearly twenty percent of people wounded by rusty metals are infected by severe tetanus. Understanding the facts about the relation between rusty metals wounds and tetanus can lessen your risk of getting the infection.

Tetanus is an infection caused by bacterium called Clostridium retain. Some people call it lockjaw, because the spasm starts in your jam before spreading to the other areas.

Tetanus causes severe muscle spasms which can ends in bone fractures. The bacteria causing tetanus can be found in soil, dust, and manure.

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It can enter your body through an open wound caused by contaminated objects. Rusty metals are commonly located outdoors or in humid places, where the bacteria Clostridium retain are more likely to reside.

In your central nervous system, it releases a toxin called tetanospasim which induce tetanus infection. Your nervous system which is attacked begins to show some symptoms of tetanus infection.

Within days, this infection will cause severe pains that some people get their bones fractured. Tetanus infection hurts you badly that sometimes painkillers are needed to calm the pain.

However, excessive consumption of painkillers might lead to kidney failure and later, death. You also need to wear gloves so that there will be no manure left beneath your fingernails, which can be dangerous for your wound.

Tetanus is caused by an infection with the bacterium Clostridium retain, which is commonly found in soil, saliva, dust, and manure. The bacteria generally enter through a break in the skin such as a cut or puncture wound by a contaminated object.

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They produce toxins that interfere with normal muscle contractions. Diagnosis is based on the presenting signs and symptoms.

Tetanus occurs in all parts of the world but is most frequent in hot and wet climates where the soil has a high organic content. An early description of the disease was made by Hippocrates in the 5th century BC.

The spasms can also affect the facial muscles resulting in an appearance called rises sardonic us. Chest, neck, back, abdominal muscles, and buttocks may be affected.

Back muscle spasms often cause arching, called opisthotonos. Prolonged muscular action causes sudden, powerful, and painful contractions of muscle groups, which is called “Titans”.

These episodes can cause fractures and muscle tears. Other symptoms include fever, headache, restlessness, irritability, feeding difficulties, breathing problems, burning sensation during urination, urinary retention and loss of stool control.

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Even with treatment, about 10% of people who contract tetanus die. The incubation period of tetanus may be up to several months, but is usually about ten days.

In general, the farther the injury site is from the central nervous system, the longer the incubation period. The shorter the incubation period, the more severe the symptoms.

On the basis of clinical findings, four different forms of tetanus have been described. The generalized form usually presents with a descending pattern.

The first sign is Erasmus, or lockjaw, and the facial spasms called rises sardonic us, followed by stiffness of the neck, difficulty in swallowing, and rigidity of pectoral and calf muscles. Spasms may occur frequently and last for several minutes with the body shaped into a characteristic form called opisthotonos.

Spasms continue for up to four weeks, and complete recovery may take months. If the mother has been vaccinated against tetanus, the infants acquire passive immunity and are thus protected.

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As the result of a public health campaign, the death toll from neonatal tetanus was reduced by 90% between 1990 and 2010, and by 2013 the disease had been largely eliminated from all but 25 countries. Neonatal tetanus is rare in developed countries.

Local tetanus is an uncommon form of the disease, in which people have persistent contraction of muscles in the same anatomic area as the injury. The contractions may persist for many weeks before gradually subsiding.

Cephalic tetanus is the rarest form of the disease (0.9–3% of cases) and is limited to muscles and nerves in the head. It usually occurs after trauma to the head area, including skull fracture, laceration, eye injury, dental extraction, and Otis media, but it has been observed from injuries to other parts of the body.

Paralysis of the facial nerve is most frequently implicated, which may cause lockjaw, facial palsy, or posts, but other cranial nerves can also be affected. Cephalic tetanus may progress to a more generalized form of the disease.

Due to its rarity, clinicians may be unfamiliar with the clinical presentation and may not suspect tetanus as the illness. Treatment can be complicated as symptoms may be concurrent with the initial injury that caused the infection.

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Tetanus is an international health problem, as C. retain endoscopes are ubiquitous. Endoscopes can be introduced into the body through a puncture wound (penetrating trauma).

Due to C. retain being an anaerobic bacterium, it and its endoscopes thrive in environments that lack oxygen, such as a puncture wound. The disease occurs almost exclusively in persons inadequately immunized.

It is more common in hot, damp climates with soil rich in organic matter. Manure -treated soils may contain spores, as they are widely distributed in the intestines and feces of many animals such as horses, sheep, cattle, dogs, cats, rats, guinea pigs, and chickens.

In agricultural areas, a significant number of human adults may harbor the organism. The spores can also be found on skin surfaces and in contaminated heroin.

Heroin users, particularly those who inject the drug subcutaneously, appear to be at high risk of contracting tetanus. Rarely, tetanus can be contracted through surgical procedures, intramuscular injections, compound fractures, and dental infections.

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Additionally, the rough surface of rusty metal provides crevices for dirt containing C. retain, while a nail affords a means to puncture skin and deliver endoscopes deep within the body at the site of the wound. An endoscope is a non-metabolizing survival structure that begins to metabolize and cause infection once in an adequate environment.

Hence, stepping on a nail (rusty or not) may result in a tetanus infection, as the low-oxygen (anaerobic) environment may exist under the skin, and the puncturing object can deliver endoscopes to a suitable environment for growth. The cleavage of the VAMP protein by the toxin inhibits vesicle fusion and neurotransmitter release into the synapse.

Tetanus neurotoxin (Tent) binds to the presynaptic membrane of the neuromuscular junction, is internalized and is transported back through the axon until it reaches the central nervous system. Here, it selectively binds to and is transported into inhibitory neurons via endocytosis.

Tetanus toxin specifically blocks the release of the neurotransmitters Gaza and glycine from inhibitory neurons. These neurotransmitters keep overactive motor neurons from firing and also play a role in the relaxation of muscles after contraction.

This causes the muscle spasms and spastic paralysis seen in tetanus infection. The N-terminal side of the heavy chain helps with membrane translocation, and the C-terminal side helps the toxin locate the specific receptor site on the correct neuron.

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The light chain domain cleaves the VAMP protein once it arrives in the inhibitory neuron cytosol. There are four main steps tetanus's mechanism of action: binding to the neuron, internalization of the toxin, membrane translocation, and cleavage of the target VAMP.

The toxin travels from the wound site to the neuromuscular junction through the bloodstream where it binds to the presynaptic membrane of a motor neuron. The heavy chain C-terminal domain aids in the binding to the correct site, recognizing and binding to the correct glycoproteins and glycolysis in the presynaptic membrane.

The toxin binds to a site that will be taken into the neuron as an endoscopic vesicle that will travel all the way down the axon, past the cell body, and down the dendrites to the dendritic terminal at the spine and central nervous system. Here it will be released into the synaptic cleft and allowed to bind with the presynaptic membrane of inhibitory neurons similarly seen with the binding to the motor neuron.

Tetanus toxin is then internalized again via endocytosis, this time in an acidic vesicle. In a mechanism not well understood, depolarization caused by the firing of the inhibitory neuron causes the toxin to be pulled into the neuron inside vesicles.

The toxin then needs a way to get out of the vesicle and into the neuron cytosol in order for it to act on its target. With the hydrophobic patches exposed, the toxin is able to slide into the vesicle membrane.

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There is a consensus among experts that this new channel is involved in the translocation of the toxin's light chain from the inside of the vesicle to the neuron cytosol, but the mechanism is not well understood or agreed upon. It has been proposed that the channel could allow the light chain (unfolded from the low pH environment) to leave through the toxin pore, or that the pore could alter the electrochemical gradient enough, by letting in or out ions, to cause osmotic lysis of the vesicle, spilling the vesicle's contents.

The light chain of the tetanus toxin is a zinc-dependent protease. It shares a common zinc protease motif (His-Glu-Xaa-Xaa-His) that researchers hypothesized was essential for target cleavage until this was more recently confirmed by experiment: when all zinc was removed from the neuron with heavy metal creators, the toxin was inhibited, only to be reactivated when the zinc was added back in.

The light chain binds to VAMP and cleaves it between Gln76 and Phe77. Without VAMP, vesicles holding the neurotransmitters needed for motor neuron regulation (Gaza and Glycine) cannot be released, causing the above-mentioned deregulation of motor neurons and muscle tension.

The diagnosis is based on the presentation of tetanus symptoms and does not depend upon isolation of the bacterium, which is recovered from the wound in only 30% of cases and can be isolated from people without tetanus. Laboratory identification of C. retain can be demonstrated only by production of tetanospasmin in mice.

Having recently experienced head trauma may indicate cephalic tetanus if no other diagnosis has been made. A positive test result is the involuntary contraction of the jaw (biting down on the “spatula”) and a negative test result would normally be a gag reflex attempting to expel the foreign object.

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A short report in The American Journal of Tropical Medicine and Hygiene states that, in an affected subject research study, the spatula test had a high specificity (zero false-positive test results) and a high sensitivity (94% of infected people produced a positive test). This is due to the extreme potency of the tetanospasmin toxin.

Tetanospasmin will likely be lethal before it will provoke an immune response. The CDC recommends that adults receive a booster vaccine every ten years, and standard care practice in many places is to give the booster to any person with a puncture wound who is uncertain of when he or she was last vaccinated, or if he or she has had fewer than three lifetime doses of the vaccine.

The booster may not prevent a potentially fatal case of tetanus from the current wound, however, as it can take up to two weeks for tetanus antibodies to form. For adults and children over seven, the TD vaccine (tetanus and diphtheria) or Trap (tetanus, diphtheria, and cellular pertussis) is commonly used.

The World Health Organization certifies countries as having eliminated maternal or neonatal tetanus. Certification requires at least two years of rates of less than 1 case per 1000 live births.

In 1998 in Uganda, 3,433 tetanus cases were recorded in newborn babies; of these, 2,403 died. After a major public health effort, Uganda in 2011 was certified as having eliminated tetanus.

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In extreme cases it may be necessary to paralyze the person with curare -like drugs and use a mechanical ventilator. In order to survive a tetanus infection, the maintenance of an airway and proper nutrition are required.

An intake of 3,500 to 4,000 calories and at least 150 g of protein per day is often given in liquid form through a tube directly into the stomach (percutaneous endoscopic gastrostomy), or through a drip into a vein (parenteral nutrition). Full recovery takes 4 to 6 weeks because the body must regenerate destroyed nerve axon terminals.

Ranging from some (in dark red) to very few (in light yellow) (gray, no data). Tetanus was well known to ancient people who recognized the relationship between wounds and fatal muscle spasms.

In 1884, Arthur Nicolai isolated the strychnine -like toxin of tetanus from free-living, anaerobic soil bacteria. The etiology of the disease was further elucidated in 1884 by Antonio Care and Giorgio Rat tone, two pathologists of the University of Turin, who demonstrated the transmissivity of tetanus for the first time.

There is insufficient evidence to recommending treating or preventing tetanus with vitamin C. ^ a b c d e f g h i j k l m n o p q r s t u v w × y z AA ab ac ad eye AF AG ah AI AJ AK all am an AO AP a AR as Atkinson, William (May 2012).


Tetanus Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention.

^ a b Los T, Allen C, Aurora M, Barber RM, Bhutto ZA, Brown A, et al. (God 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016). “Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015”.

^ a b Wang H, Safari M, Allen C, Barber RM, Bhutto ZA, Carter A, et al. (God 2015 Mortality and Causes of Death Collaborators) (October 2016). “Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015”.

^ a b Safari M, Wang H, Loan R, Davis A, Liang X, Zhou M, et al. (God 2013 Mortality and Causes of Death Collaborators) (January 2015). “Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013”.

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“Changes in severe accidental tetanus mortality in the ICU during two decades in Brazil”. ^ a b c Dosh A, Darrell C, Daedalus D, Pullman D (February 2014).

Cephalic tetanus presenting as a stroke mimic”. ^ a b c Del Polar Morales E, Bertrand Parallel J, Cardona Rodriguez Z, Almodovar Mercado JC, Figueroa Navarro A (2014).

“Cephalic tetanus following penetrating eye trauma: a case report”. ^ a b c d Adele ye AO, Azeem AL (October 2012).

“Cephalic tetanus following tooth extraction in a Nigerian woman”. “Erasmus in cephalic tetanus from a foot injury”.

^ a b c SEO DH, CHO DK, Won HC, Kim TU (February 2012). “A case of cephalic tetanus with unilateral posts and facial palsy”.

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^ O'Connor, Anaheim (February 22, 2005), “The Claim: Stepping on a Rusty Nail Can Cause Tetanus ", The New York Times Jennings K (2013-10-08). The Truth Behind the Myths, Tales, and Warnings Every Generation Passes Down to Its Kids.

^ a b c d e Pellizzari R, Rossetti O, Schizo G, Montecucco C (February 1999). Tetanus and botulinum neurotoxin: mechanism of action and therapeutic uses”.

Philosophical Transactions of the Royal Society of London. “Mechanism of action of tetanus and botulinum neurotoxin”.

“The structure of the tetanus toxin reveals pH-mediated domain dynamics”. “Pore formation by tetanus toxin, its chain and fragments in neuronal membranes and evaluation of the underlying motifs in the structure of the toxin molecule”.

^ Cabinet V, Large P, Vandenbranden M, Flamage P, Ruysschaert JM (April 1985). “ Tetanus toxin induces fusion and aggregation of lipid vesicles containing phosphatidylinositol at low pH”.

^ Foreign P, Shone CC, Dolly JO (December 1994). “Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments”.

^ a b “Diphtheria, tetanus, and pertussis: recommendations for vaccine use and other preventive measures. Recommendations of the Immunization Practices Advisory committee (Acid)”.

^ Porter JD, Perkins MA, Corbel MJ, Farrington CP, Watkins JT, Egg NT (1992). “Lack of early antitoxin response to tetanus booster”.

^ “Uganda announces elimination of Maternal and Neonatal Tetanus ". “Current recommendations for treatment of tetanus during humanitarian emergencies”.

Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2). Anthony S. Fauci, Dennis L. Jasper, Stephen L. Mauser, Dan L. Long, Joseph Local.

^ Rodrigo, Chaturthi; Fernando, Deepika; Rajapakse, Sen aka (2014). ^ “Maternal and Neonatal Tetanus Elimination Initiative” (PDF).

^ Black RE, Cousins S, Johnson HL, Lawn JE, Sudan I, Assani DG, et al. (June 2010). “Global, regional, and national causes of child mortality in 2008: a systematic analysis”.

Wikipedia's health care articles can be viewed offline with the Medical Wikipedia app. Wikimedia Commons has media related to Tetanus.

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